Abstract Title:

Acetylcholinesterase inhibition by flavonoids from Agrimonia pilosa.

Abstract Source:

Molecules. 2007;12(9):2130-9. Epub 2007 Sep 3. PMID: 17962731

Abstract Author(s):

Mankil Jung, Moonso Park

Abstract:

In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin (4), which showed twice the activity of dehydroevodiamine (DHED).

Study Type : In Vitro Study
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