Ailanthus inhibts HIV-1 fusion. - GreenMedInfo Summary
Abstract Title:
Korean medicinal plants inhibiting to human immunodeficiency virus type 1 (HIV-1) fusion.
Abstract Source:
Phytother Res. 2003 Apr;17(4):426-9. PMID: 12722157
Article Affiliation:
College of Pharmacy, Chosun University, Kwangju 501-759, Republic of Korea.
Abstract:
In order to find novel anti-HIV agents from natural products, 80 MeOH extracts of Korean plants were applied to a syncytia formation inhibition assay, which is based on the interaction between the HIV-1 envelope glycoprotein gp120/41 and the cellular membrane protein CD4 of T lymphocytes. The most potent HIV-1 fusion inhibition was shown by the stem bark of Ailanthus altissima with 74.9 +/- 4.4% at a concentration of 100 microg/mL.
Article Published Date : Apr 01, 2003
Study Type : Animal Study
Additional Links
Substances : Ailanthus altissima : CK(2) : AC(1)
Diseases : HIV Infections : CK(849) : AC(260)
Pharmacological Actions : Anti-HIV Agents : CK(111) : AC(63), HIV Fusion Inhibitors : CK(5) : AC(4)
Additional Keywords : Plant Extracts : CK(11762) : AC(4236)