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Ailanthus inhibts HIV-1 fusion. - GreenMedInfo Summary

Abstract Title:

Korean medicinal plants inhibiting to human immunodeficiency virus type 1 (HIV-1) fusion.

Abstract Source:

Phytother Res. 2003 Apr;17(4):426-9. PMID: 12722157

Abstract Author(s):

Young-Su Chang, Eun-Rhan Woo

Article Affiliation:

College of Pharmacy, Chosun University, Kwangju 501-759, Republic of Korea.

Abstract:

In order to find novel anti-HIV agents from natural products, 80 MeOH extracts of Korean plants were applied to a syncytia formation inhibition assay, which is based on the interaction between the HIV-1 envelope glycoprotein gp120/41 and the cellular membrane protein CD4 of T lymphocytes. The most potent HIV-1 fusion inhibition was shown by the stem bark of Ailanthus altissima with 74.9 +/- 4.4% at a concentration of 100 microg/mL.

Study Type : Animal Study

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