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Article Publish Status: FREE
Abstract Title:

Alcohol Extracts FromDelay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents.

Abstract Source:

Front Pharmacol. 2019 ;10:272. Epub 2019 Mar 26. PMID: 30971923

Abstract Author(s):

Guoxiao Lai, Yinrui Guo, Diling Chen, Xiaocui Tang, Ou Shuai, Tianqiao Yong, Dongdong Wang, Chun Xiao, Gailian Zhou, Yizhen Xie, Burton B Yang, Qingping Wu

Article Affiliation:

Guoxiao Lai

Abstract:

Age-related changes in methylation are involved in the occurrence and development of tumors, autoimmune disease, and nervous system disorders, including Alzheimer's disease (AD), in elderly individuals; hence, modulation of these methylation changes may be an effective strategy to delay the progression of AD pathology. In this study, the AD model rats were used to screen the main active extracts from the mushroom,, for anti-aging properties, and their effects on DNA methylation were evaluated. The results of evaluation of rats treated with 100 mg/kg/day of D-galactose to induce accelerated aging showed that alcohol extracts ofcontained the main active anti-aging extract. The effects on DNA methylation of theseextracts were then evaluated using SAMP8 and APP/PS1 AD model mice by whole genome bisulfite sequencing, and some methylation regulators including Histone H3, DNMT3A, and DNMT3B in brain tissues were up-regulated after treatment with alcohol extracts from. Molecular docking analysis was carried out to screen for molecules regulated by specific components, including ganoderic acid Mk, ganoderic acid C6, and lucidone A, which may be active ingredients of, including the methylation regulators of Histone H3, MYT, DNMT3A, and DNMT3B. Auxiliary tests also demonstrated thatalcohol extracts could improve learning and memory function, ameliorate neuronal apoptosis and brain atrophy, and down-regulate the expression of the AD intracellular marker, Aβ. We concluded that alcohol extracts from, including ganoderic acid and lucidone A, are the main extracts involved in delaying AD progression.

Study Type : Animal Study

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