Article Publish Status: FREE
Abstract Title:

Allicin Could Potentially Alleviate Oral Cancer Pain by Inhibiting"Pain Mediators"TNF-alpha, IL-8, and Endothelin.

Abstract Source:

Curr Issues Mol Biol. 2021 May 23 ;43(1):187-196. Epub 2021 May 23. PMID: 34071008

Abstract Author(s):

Abdulwahab H Alamir, Shankargouda Patil

Article Affiliation:

Abdulwahab H Alamir


To evaluate the effects of allicin on mediators of pain secreted by oral cancer cells in vitro, single-cell suspensions were prepared by enzymatic method from oral squamous cell carcinoma (OSCC). Cancer stem cells were isolated by the CD133+ selection method with magnetic cell sorting. Stemness markers were checked in both cancer cells and cancer stem cells by RT-PCR. Comparative analysis of pain mediators TNF-alpha, IL-8, and endothelin at both RNA and protein levels for normal epithelial cells, cancer cells, and cancer stem cells was carried out with and without allicin treatment. CD133 and CD44 expression levels were checked in cancer cells and cancer stem cells flow cytometrically. Allicin inhibited both gene and protein expression of TNF-alpha, IL-8, and endothelin in both cancer cells and cancer stem cells. Allicin is more likely to be a promising treatment in alleviating the levels of pain and inflammation in OSCCs.

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Sayer Ji
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