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Abstract Title:

Allicin modulates diclofenac sodium induced hepatonephro toxicity in rats via reducing oxidative stress and caspase 3 protein expression.

Abstract Source:

Environ Toxicol Pharmacol. 2019 Nov 23 ;74:103306. Epub 2019 Nov 23. PMID: 31812117

Abstract Author(s):

Sahar Hassan Orabi, Doaa Abd Eldaium, Azza Hassan, Hesham Saad El Sabagh, Mabrouk Attia Abd Eldaim

Article Affiliation:

Sahar Hassan Orabi

Abstract:

PURPOSE: This study was designed to evaluate the protective effects of allicin against diclofenac sodium induced hepatonephro toxicity in rats.

METHODS: Sixty male Wister albino rats were assigned into six groups. The control group received calcium carbonate and corn starch. 2group received diclofenac sodium (2 mg/kg bw orally) for 30 days. 3group received allicin (45 mg/kg bw orally) for 30 days. 4group administrated diclofenac sodium as in the 2group and allicin (15 mg/kg bw orally) for 30 days. 5group received diclofenac sodium as in the 2group and allicin (30 mg/kg bw orally) for 30 days. 6group received diclofenac sodium as 2and allicin (45 mg/kg bw orally) for 30 days.

RESULTS: Diclofenac sodium significantly elevated activities of serum aspartate aminotransferase and alanine aminotransferase and serum levels of creatinine and urea. In addition, it induced hyperglycemia, lipid peroxidation, pathological alteration and caspase 3 protein expression in hepatic and renal tissues. However, it decreased reduced glutathione concentration and proliferating cell nuclear antigen protein expression in hepatic tissues. In contrast, allicin modulated the diclofenac sodium induced alteration in liver and kidney functions and structures dose dependently.

CONCLUSION: This study indicated that allicin had potential preventive effects against diclofenac sodium induced hepatonephro toxicity in rats.

Study Type : Animal Study

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