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Abstract Title:

Anti-nociceptive and anti-inflammatory activities of (-)-α-bisabolol in rodents.

Abstract Source:

Naunyn Schmiedebergs Arch Pharmacol. 2011 Dec ;384(6):525-33. Epub 2011 Aug 26. PMID: 21870032

Abstract Author(s):

Nayrton Flávio Moura Rocha, Emiliano Ricardo Vasconcelos Rios, Alyne Mara Rodrigues Carvalho, Gilberto Santos Cerqueira, Amanda de Araújo Lopes, Luzia Kalyne Almeida Moreira Leal, Marília Leite Dias, Damião Pergentino de Sousa, Francisca Cléa Florenço de Sousa

Article Affiliation:

Nayrton Flávio Moura Rocha

Abstract:

(-)-α-Bisabolol is an unsaturated, optically active sesquiterpene alcohol obtained by the direct distillation of essential oil from plants such as Vanillosmopsis erythropappa and Matricaria chamomilla. (-)-α-Bisabolol has generated considerable economic interest, as it possesses a delicate floral odour and has been shown to have antiseptic and gastroprotective activities. In this study, (-)-α-bisabolol was tested in standardised rodent models by gavage administration at doses of 100 and 200 mg/kg in the models of inflammation and 25 and 50 mg/kg in the models of nociception. In the inflammatory models of paw oedema induced by carrageenan and dextran, the mice treated with (-)-α-bisabolol showed smaller oedemas compared to animals treated only with the vehicle. (-)-α-Bisabolol was capable of reducing paw oedemas induced by 5-HT but not oedemas induced by histamine. (-)-α-Bisabolol demonstrated anti-nociceptive activity in the models of visceral nociception induced by acetic acid and in the second phase of the nociception test induced by the intraplantar administration of formalin. (-)-α-Bisabolol did not have any effect in a thermal nociception model using a hot plate but was able to diminish mechanical inflammatory hypernociception evoked by carrageenan. These findings suggest that the anti-nociceptive action of (-)-α-bisabolol is not linked to a central mechanism but instead is related to the inflammatory process. (-)-α-Bisabolol was able to decrease leukocyte migration, protein extravasations and the amount of TNF-α to the peritoneal cavity in response to carrageenan. Additionally, (-)-α-bisabolol reduced neutrophil degranulation in response to phorbol-myristate-acetate. We demonstrate, for the first time, the peripheral anti-inflammatory and anti-nociceptiveactivities of (-)-α-bisabolol.

Study Type : Animal Study

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