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Abstract Title:

alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells.

Abstract Source:

Biochem Biophys Res Commun. 2004 Mar 12 ;315(3):589-94. PMID: 14975741

Abstract Author(s):

Elisabetta Cavalieri, Sofia Mariotto, Cinzia Fabrizi, Alessandra Carcereri de Prati, Rossella Gottardo, Stefano Leone, Luigi Valentino Berra, Giuliana Maria Lauro, Anna Rosa Ciampa, Hisanori Suzuki

Article Affiliation:

Elisabetta Cavalieri

Abstract:

In this study, alpha-bisabolol, a sesquiterpene alcohol present in natural essential oil, was found to have a strong time- and dose-dependent cytotoxic effect on human and rat glioma cells. After 24 h of treatment with 2.5-3.5 microM alpha-bisabolol, the viability of these cells was reduced by 50% with respect to untreated cells. Furthermore, the viability of normal rat glial cells was not affected by treatment with alpha-bisabolol at the same concentrations as above. Glioma cells treated with high concentration of alpha-bisabolol (10 microM) resulted in a 100% cell death. Judging from hypo-G1 accumulation, poly(ADP-ribose) polymerase cleavage, and DNA ladder formation, the cytotoxicity triggered by alpha-bisabolol resulted from apoptosis induction. Moreover, the dissipation of mitochondrial-inner transmembrane potential and the release of cytochrome c from mitochondria indicated that, in these glioma cells, apoptosis occurred through an intrinsic pathway. As pointed out by the experimental results, alpha-bisabolol may be considered a novel compound able to inhibit glioma cell growth and survival.

Study Type : Human In Vitro

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