Alpha-lipoic acid could prove useful as adjunctive therapy for schizophrenia. - GreenMedInfo Summary
α-Lipoic Acid as Adjunctive Treatment for Schizophrenia: An Open-Label Trial.
J Clin Psychopharmacol. 2017 Oct 19. Epub 2017 Oct 19. PMID: 29053478
Lia Lira Olivier Sanders
PURPOSE/BACKGROUND: Accumulating evidence suggests an involvement of oxidative stress in the pathophysiology of schizophrenia. This offers a hypothesis-derived therapeutic approach to hinder oxidative damage and its clinical sequelae.α-Lipoic acid (ALA) is a powerful natural antioxidant indicated to treat diabetic neuropathy.
METHODS/PROCEDURES: In this pilot investigation, we administered ALA (100 mg/d) for 4 months, as an adjunct to antipsychotic medication, to 10 patients with schizophrenia.
FINDINGS/RESULTS: We found robust improvement in measures of psychopathology (63.9% reduction in Brief Psychiatric Rating Scale scores), neurocognitive parameters, extrapyramidal symptoms, and decreased lipid peroxidation.
IMPLICATIONS/CONCLUSIONS: If larger, double-blind, placebo-controlled studies confirm these preliminary findings, ALA could prove useful as adjunctive therapy for schizophrenia.