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Abstract Title:

α-Lipoic Acid as Adjunctive Treatment for Schizophrenia: An Open-Label Trial.

Abstract Source:

J Clin Psychopharmacol. 2017 Oct 19. Epub 2017 Oct 19. PMID: 29053478

Abstract Author(s):

Lia Lira Olivier Sanders, Carlos Eduardo de Souza Menezes, Adriano José Maia Chaves Filho, Glautemberg de Almeida Viana, Francisco Vagnaldo Fechine, Maria Goretti Rodrigues de Queiroz, Said Gonçalvez da Cruz Fonseca, Silvânia Maria Mendes Vasconcelos, Maria Elisabete Amaral de Moraes, Clarissa S Gama, Sheila Seybolt, Eugênio de Moura Campos, Danielle Macêdo, David Freitas de Lucena

Article Affiliation:

Lia Lira Olivier Sanders

Abstract:

PURPOSE/BACKGROUND: Accumulating evidence suggests an involvement of oxidative stress in the pathophysiology of schizophrenia. This offers a hypothesis-derived therapeutic approach to hinder oxidative damage and its clinical sequelae.α-Lipoic acid (ALA) is a powerful natural antioxidant indicated to treat diabetic neuropathy.

METHODS/PROCEDURES: In this pilot investigation, we administered ALA (100 mg/d) for 4 months, as an adjunct to antipsychotic medication, to 10 patients with schizophrenia.

FINDINGS/RESULTS: We found robust improvement in measures of psychopathology (63.9% reduction in Brief Psychiatric Rating Scale scores), neurocognitive parameters, extrapyramidal symptoms, and decreased lipid peroxidation.

IMPLICATIONS/CONCLUSIONS: If larger, double-blind, placebo-controlled studies confirm these preliminary findings, ALA could prove useful as adjunctive therapy for schizophrenia.

Study Type : Human Study

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