Article Publish Status: FREE
Abstract Title:

Alpha-lipoic acid inhibits lung cancer growth via mTOR-mediated autophagy inhibition.

Abstract Source:

FEBS Open Bio. 2020 Feb 23. Epub 2020 Feb 23. PMID: 32090494

Abstract Author(s):

Peipei Peng, Xiaojin Zhang, Tao Qi, Hao Cheng, Qiuyue Kong, Li Liu, Xiaofei Cao, Zhengnian Ding

Article Affiliation:

Peipei Peng


Lung cancer is the leading cause of cancer-related death, and there remains a need for novel therapies for this malignancy. Here, we examined the effects of alpha-lipoic acid (LA), a drug used for treating human diabetic complications, on lung cancer growth. We report that LA limited lung cancer growth in xenograft mice and reduced lung cancer A549 cell viability. We observed autophagy activation in human lung cancers, and report that LA inactivated autophagy in A549 cells. In addition, LA activated mTOR/p70S6K signaling. Inhibition of mTOR with rapamycin reversed LA-induced inactivation of autophagy and abolished LA-induced suppression of A549 cell viability. Altogether, the data suggest that LA exerts an anti-lung cancer effect through mTOR-mediated inhibition of autophagy, and thus LA may have therapeutic potential for lung cancer management.

Study Type : In Vitro Study

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