Protective effect ofα-lipoic acid against radiation-induced fibrosis in mice.
Oncotarget. 2016 Jan 20. Epub 2016 Jan 20. PMID: 26799284
Radiation-induced fibrosis (RIF) is one of the most common late complications of radiation therapy. We found thatα-lipoic acid (α-LA) effectively prevents RIF. In RIF a mouse model, leg contracture assay was used to test the in vivo efficacy of α-LA. α-LA suppressed the expression of pro-fibrotic genes after irradiation, both in vivo and in vitro, and inhibited the up-regulation of TGF-β1-mediated p300/CBP activity. Thus, α-LA prevents radiation-induced fibrosis (RIF) by inhibiting the transcriptional activity of NF-κB through inhibition of histone acetyltransferase activity. α-LA is a new therapeutic methods that can be used in the prevention-treatment of RIF.