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Abstract Title:

Alpha-Santalol, a Component of Sandalwood Oil Inhibits Migration of Breast Cancer Cells by Targeting theβ-catenin Pathway.

Abstract Source:

Anticancer Res. 2018 08 ;38(8):4475-4480. PMID: 30061212

Abstract Author(s):

Ajay Bommareddy, Kacey Knapp, Abigail Nemeth, James Steigerwalt, Terra Landis, Adam L Vanwert, Harsha P Gorijavolu, Chandradhar Dwivedi

Article Affiliation:

Ajay Bommareddy

Abstract:

BACKGROUND/AIM: Alpha-santalol, a terpenoid found in sandalwood oil has been shown to inhibit breast cancer cell growth in vitro by inducing apoptosis, but the mechanisms underlying the growth inhibitory effects of alpha-santalol are not fully understood. In this study, we demonstrate thatα-santalol treatment targets Wnt/β-catenin pathway to inhibit migration of cultured breast cancer cells.

MATERIALS AND METHODS: Migration assays, immunoblotting and immunofluorescence were used to examine the mechanism of action of a-santalol in breast cancer cells.

RESULTS: Exposure of MDA-MB 231 and MCF-7 cells toα-santalol resulted in a significant reduction in their migratory potential and wound healing ability. In addition, α-santalol affected the localization of β-catenin from cytosol to nucleus in MDA-MB 231 cells.

CONCLUSION: Alpha-santalol inhibited migration of breast cancer cells may be mediated, in part, by targeting Wnt//β-catenin pathway. β-catenin represents an important target of α-santalol's response for future pre-clinical studies.

Study Type : In Vitro Study

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