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Abstract Title:

New Rev-export inhibitor from Alpinia galanga and structure-activity relationship.

Abstract Source:

Bioorg Med Chem Lett. 2009 May 1;19(9):2555-7. Epub 2009 Mar 17. PMID: 19342232

Abstract Author(s):

Satoru Tamura, Atsushi Shiomi, Masafumi Kaneko, Ying Ye, Minoru Yoshida, Masayuki Yoshikawa, Tominori Kimura, Motomasa Kobayashi, Nobutoshi Murakami

Article Affiliation:

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.

Abstract:

Bioassay-guided separation by use of the fission yeast expressing NES of Rev, an HIV-1 viral regulatory protein, disclosed 1'-acetoxychavicol acetate (ACA, 1) as a new inhibitor for nuclear export of Rev from the roots of Alpinia galanga. Both analysis for mechanism of action with biotinylated probe (2) and several synthesized analogs established crucial portions in 1 for Rev-export inhibitory activity.

Study Type : In Vitro Study

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