Amelioration of oxidative stress by dietary fenugreek (Trigonella foenum-graecum L.) seeds is potentiated by onion (Allium cepa L.) in streptozotocin-induced diabetic rats.
Appl Physiol Nutr Metab. 2017 Mar 20. Epub 2017 Mar 20. PMID: 28319671
Seetur R Pradeep
Oxidative stress has a crucial role in the progression of diabetes and its complications. Soluble fibre-rich fenugreek seeds (Trigonella foenum-graecum L.) are understood to have a beneficial effect in the management of diabetes. Previously, we have shown that the amelioration of diabetic hyperglycemia and related metabolic abnormalities was potentiated by onion (Allium cepa L.) in experimental rats. The present study evaluated the additive beneficial effect of dietary fenugreek seeds (10%) and onion (3%) on oxidative stress in diabetic rats. These dietary interventions lowered oxidative stress, the combination producing a higher beneficial effect (p<0.05), although not additive. Dietary fenugreek, onion, or fenugreek+onion countered hypercholesterolemia (p<0.05), especially from LDL-associated fraction by 43, 35, and 54%, respectively. The elevated hepatic and heart cholesterol, triglycerides and phospholipids under diabetic conditions were significantly encountered by these dietary interventions, where the effect being higher with the combination, amounting to an additive effect. These findings were also corroborated by restoration of histopathological abnormalities of heart and liver tissues along with lowered heart and liver weights. It is inferred that an alleviation of oxidative stress contributes further to the antidiabetic influence and this nutraceutical potential of fenugreek seeds and onion was higher when these two were consumed together.