Ameliorative effects ofon cuprizone-induced memory decline in rat model of multiple sclerosis.
Anat Cell Biol. 2018 Jun ;51(2):119-127. Epub 2018 Jun 27. PMID: 29984057
Gabriel Olaiya Omotoso
Cuprizone is a neurotoxin with copper-chelating ability used in animal model of multiple sclerosis in which oxidative stress has been documented as one of the cascade in the pathogenesis.is a phytomedicinal plant with antioxidant and neuroprotective properties. This study aimed at evaluating the ameliorative capability ofin cuprizone-induced behavioral and histopathological alterations in the prefrontal cortex and hippocampus of Wistar rats. Four groups of rats were treated with normal saline, cuprizone,and a combination ofand cuprizone, for five weeks. The rats were subjected to Morris water maze and Y-maze to assess long and short-term memory respectively. The animals were sacrificed, and brain tissues were removed for histochemical and enzyme lysate immunosorbent assay for catalase, superoxide dismutase, and nitric oxide. Cuprizone significantly induced oxidative and nitrosative stress coupled with memory decline and cortico-hippocampal neuronal deficits; however, administration ofsignificantly reversed the neuropathological deficits induced by cuprizone.