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Article Publish Status: FREE
Abstract Title:

Analgesic and anti-inflammatory actions on bradykinin route of a polysulfated fraction from alga Ulva lactuca.

Abstract Source:

Int J Biol Macromol. 2016 Nov ;92:820-830. Epub 2016 Jul 29. PMID: 27481342

Abstract Author(s):

Ianna Wivianne Fernandes de Araújo, José Ariévilo Gurgel Rodrigues, Ana Luíza Gomes Quinderé, Jane de Fátima Teixeira Silva, Gabrielle de Freitas Maciel, Natássia Albuquerque Ribeiro, Edfranck de Sousa Oliveira Vanderlei, Kátia Alves Ribeiro, Hellíada Vasconcelos Chaves, Karuza Maria Alves Pereira, Mirna Marques Bezerra, Norma Maria Barros Benevides

Article Affiliation:

Ianna Wivianne Fernandes de Araújo

Abstract:

We investigated structural features of polysaccharides from Ulva lactuca and their effects on the classical models of nociception and inflammation. Crude extract was obtained by enzymatic digestion and isolated by ion exchange chromatography on DEAE-cellulose. The fraction with higher yield was used in the tests (SP-Ul). Swiss mice received SP-Ul (1, 3 or 9mg/kg; i.v.), 30min prior to injection of 0.8%-acetic acid or 1%-formalin or prior to a thermal stimulus. At same doses, SP-Ul was tested on Wistar rats on paw edema elicited by different irritants (carrageenan, dextran, bradykinin, histamine or serotonin). The results of infrared characterization indicated the presence of hydroxyl groups, sulfate, uronic acid and glycosidic linkages in all SP fractions spectrums. SP-Ul decreased significantly the antinociception in response to acetic acid or formalin (second phase), but not in the hot-plate test, suggesting that its analgesia occurs through a peripheral mechanism. SP-Ul did not reduce carrageenan-induced paw edema as supported by both histological and myeloperoxidase activity assessments. However, SP-Ul (1mg/kg; s.c.) reduced dextran-elicited edema, showing vascular anti-inflammatory effect, with bradykinin as major target because it did not reduce histamine- and serotonin-induced paw edemas. Therefore, SP-Ul acts on bradykinin pathway in its antinociceptive and anti-inflammatory responses.

Study Type : Animal Study

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