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Article Publish Status: FREE
Abstract Title:

Andrographolide nanoparticles in leishmaniasis: characterization and in vitro evaluations.

Abstract Source:

Int J Nanomedicine. 2010 Dec 9 ;5:1113-21. Epub 2010 Dec 9. PMID: 21270962

Abstract Author(s):

Partha Roy, Suvadra Das, Tanmoy Bera, Subhasis Mondol, Arup Mukherjee

Article Affiliation:

Partha Roy

Abstract:

Andrographolide (AG) is a diterpenoid lactone isolated from the leaves of Andrographis paniculata. AG is a potent and low-toxicity antileishmanial agent. Chemotherapy applications of AG are, however, seriously constrained because of poor bioavailability, short plasma half-life, and inappropriate tissue localization. Nanoparticulation of AG was therefore envisaged as a possible solution. AG nanoparticles (AGnp) loaded in 50:50 poly(DL-lactide-co-glycolic acid) were prepared for delivery into the monocyte-macrophage cells infested with the amastigote form of leishmanial parasite for evaluation in the chemotherapy of leishmaniasis. Particle characteristics of AGnp were optimized by proportionate application of a stabilizer, polyvinyl alcohol (PVA). Physicochemical characterization of AGnp by photon correlation spectroscopy exhibited an average particle size of 173 nm and zeta potential of -34.8 mV. Atomic force microscopy visualization revealed spherical nanoparticles with a smooth surface. Antileishmanial activity was found to be significant for the nanoparticle preparation with 4% PVA (IC₅₀) 34 μM) in about one-fourth of the dosage of the pure compound AG (IC₅₀) 160 μM). AGnp therefore have significant potential to target the infested macrophage cells and prove valuable in chemotherapy of neglected tropical diseases such as leishmaniasis.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Leishmanicidal : CK(118) : AC(79)

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