n/a
Article Publish Status: FREE
Abstract Title:

Anti-brain cancer activity of chloroform and hexane extracts ofMiers: anperspective.

Abstract Source:

Ann Neurosci. 2019 Jan ;26(1):10-20. Epub 2019 Jan 1. PMID: 31975767

Abstract Author(s):

Anuradha Sharma, Sandeep Kaur Saggu, Rachana Mishra, Gurcharan Kaur

Article Affiliation:

Anuradha Sharma

Abstract:

Background: Plants have been suggested as safest source of therapeutic agents, with multi targeted mode of action and least side effects.commonly known as Guduchi in India, is one of the most highly valued herbs in Ayurvedic medicine. It possesses potential anti-cancer, anti-inflammatory, hepatoprotective, anti-diabetic, immune-stimulatory and various other beneficial activities.

Purpose: The present study was aimed to investigate the differentiation inducing potential of chloroform and hexane extracts ofusing U87MG glioblastoma and IMR-32 neuroblastoma cell lines as model system.

Results: Chloroform (Chl-TCE) and hexane (Hex-TCE) extracts significantly reduced the rate of proliferation and induced cell differentiation as evidenced by MTT assay and immunostaining for GFAP and MAP-2 in glioblastoma and neuroblastoma, respectively. Further these extracts increased the expression of stress markers HSP70 and Mortalin and induced senescence. Chloroform and hexane extracts also inhibited the migration of U87MG glioblastoma and IMR-32 neuroblastoma as indicated by wound scratch assay and supported by reduced expression of NCAM. Furthermore these extracts are not toxic to normal cells as they showed no inhibitory effects on primary astrocytic and neuronal cultures.

Conclusions: The present study suggests that chloroform and hexane extracts ofretard the rate of proliferation, induce differentiation and inhibit migration of human glioblastomas and neuroblastomas, thus may act as potential phytotherapeutic intervention in treatment of neural cancers.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.