Anti-breast cancer triterpenoid saponins from the thorns of Gleditsia sinensis. - GreenMedInfo Summary
Anti-breast cancer triterpenoid saponins from the thorns of.
Nat Prod Res. 2019 Aug ;33(16):2308-2313. Epub 2018 Feb 23. PMID: 29473437
One new triterpenoid saponin (), as well as six known ones (), were isolated from the ethanol extract of the thorns of. Their structures were elucidated by extensive spectroscopic analysis in conjunction with chemical evidence. Cytotoxic activity of compoundswas evaluated against human breast cancer MCF 7 cellsby the MTT method. Our results revealed moderate activities for compoundswith ICvalues of 18.43, 30.47, 18.46, 10.02, 30.76, and 17.32 μM, respectively. Furthermore, compounds,,, andinduced apoptosis in MCF 7 cell, withandcausing late apoptosis of MCF 7 cells, whileandacting oppositely.