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Article Publish Status: FREE
Abstract Title:

Anti-Cancer Effects of Carnosine-A Dipeptide Molecule.

Abstract Source:

Molecules. 2021 Mar 16 ;26(6). Epub 2021 Mar 16. PMID: 33809496

Abstract Author(s):

Monica D Prakash, Sarah Fraser, Jennifer C Boer, Magdalena Plebanski, Barbora de Courten, Vasso Apostolopoulos

Article Affiliation:

Monica D Prakash

Abstract:

BACKGROUND: Carnosine is a dipeptide molecule (β-alanyl-l-histidine) with anti-inflammatory, antioxidant, anti-glycation, and chelating properties. It is used in exercise physiology as a food supplement to increase performance; however, in vitro evidence suggests that carnosine may exhibit anti-cancer properties.

METHODS: In this study, we investigated the effect of carnosine on breast, ovarian, colon, and leukemic cancer cell proliferation. We further examined U937 promonocytic, human myeloid leukemia cell phenotype, gene expression, and cytokine secretion to determine if these are linked to carnosine's anti-proliferative properties.

RESULTS: Carnosine (1) inhibits breast, ovarian, colon, and leukemic cancer cell proliferation; (2) upregulates expression of pro-inflammatory molecules; (3) modulates cytokine secretion; and (4) alters U937 differentiation and phenotype.

CONCLUSION: These effects may have implications for a role for carnosine in anti-cancer therapy.

Study Type : In Vitro Study

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Sayer Ji
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