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Article Publish Status: FREE
Abstract Title:

Anti-fibrotic effect of rosmarinic acid on inhibition of pterygium epithelial cells.

Abstract Source:

Int J Ophthalmol. 2018 ;11(2):189-195. Epub 2018 Feb 18. PMID: 29487805

Abstract Author(s):

Ya-Yu Chen, Chia-Fang Tsai, Ming-Chu Tsai, Wen-Kang Chen, Yu-Wen Hsu, Fung-Jou Lu

Article Affiliation:

Ya-Yu Chen

Abstract:

AIM: To investigate the anti-fibrosis effect of rosmarinic acid (RA) in pterygium epithelial cells (PECs) to determine if RA is a potent agent for treating pterygium.

METHODS: The PECs (1×10cells/mL) were treated with 100µmol/L of RA for 1, 3 and 6h. After RA treatment, the cell viability was determined by staining with acridine orange/DAPI and analysisa NucleoCounter NC-3000. The protein expression levels of type I collagen, transforming growth factor beta-1 (TGF-β1), TGF-β type II receptor (TGF-βRII), p-Smad1/5, p-Smad2, p-Smad3, and Smad4 of the cell lysates were measured by Western blot analysis.

RESULTS: The cell viability of PECs was significantly decreased after RA treatment (<0.01). As the result, RA reduced the protein expression of type I collagen and TGF-β1 of PECs. Additionally, RA also inhibited TGF-β1/Smad signaling by decreasing the protein expressions of TGF-βRII, p-Smad1/5, p-Smad2, p-Smad3, and Smad4.

CONCLUSION: This study demonstrate that RA could inhibit fibrosis of PECs by down-regulating type I collagen expression and TGF-β1/Smad signaling. Therefore, RA is a potent therapeutic agent for the treatment of pterygium.

Study Type : In Vitro Study

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