The anti-hepatocellular carcinoma activity of Mel-P15 is mediated by natural killer cells. - GreenMedInfo Summary
The anti-hepatocellular carcinoma activity of Mel-P15 is mediated by natural killer cells.
Oncol Lett. 2017 Dec ;14(6):6901-6906. Epub 2017 Sep 21. PMID: 29163709
Mel-P15 is a peptide derived from melittin, the main toxic component in the venom of the European honeybee. In the present study, the antitumor effects of Mel-P15 and the underlying molecular mechanisms of these effectswere investigated. Mel-P15 directly stimulated natural killer (NK) cell cytotoxicity, which was increased to 55.45% at a 4µg/ml dose of Mel-P15. In the mouse liver cancer (H22) xenograft mice model, Mel-P15 suppressed tumor growth; the tumor inhibitory rate was 61.15% following treatment with 2 mg/kg Mel-P15. In addition, the immune response was activated following Mel-P15 treatment. Mel-P15 treatment increased the spleen and thymus indices, promoted splenocyte proliferation, stimulated NK cytotoxicity and upregulated the secretion of cytokines, including interleukin-2, interferon-γ and tumor necrosis factor-α. In addition, the tumor inhibitory effect of Mel-P15 on BEL-7402-bearing nude mice was abrogated by the selective depletion of NK cells via the intraperitoneal injection of an anti-asialo GM-1 antibody. The results suggest that Mel-P15 inhibits tumor growthby promoting NK cell cytotoxicity. Mel-P15 may therefore be a potential immunotherapy candidate for the treatment of hepatocellular carcinoma.