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Abstract Title:

Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora.

Abstract Source:

Arch Pharm Res. 2010 May ;33(5):697-701. Epub 2010 May 29. PMID: 20512467

Abstract Author(s):

Wei-Lie Xiao, Rui-Rui Wang, Wei Zhao, Ren-Rong Tian, Shan-Zhai Shang, Liu-Meng Yang, Jian-Hong Yang, Jian-Xin Pu, Yong-Tang Zheng, Han-Dong Sun

Article Affiliation:

Wei-Lie Xiao

Abstract:

This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), and seven known lignans (2-8). The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1-5 and 7-8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1(IIIB) induced syncytium formation with EC(50) values in the range of 2.26 approximately 20.4 microg/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1(IIIB) inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively.

Study Type : In Vitro Study

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