Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from.
Mar Drugs. 2019 Oct 16 ;17(10). Epub 2019 Oct 16. PMID: 31623220
Oxidative stress contributes to chronic inflammatory processes implicated in aging, referred to as"inflamm-aging."In this study, the potential anti-inflammatory and anti-aging effects of a pigment-protein complex (PPC) fromwere investigated using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and D-galactose (D-gal)-induced aging in a murine model. Results indicated that PPC inhibits the production of the inflammatory cytokines TNF-α and IL-6, and the inflammatory mediator nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. It also protected mice from D-gal induced informatory aging by increasing the activity of the antioxidant enzyme, such as superoxide dismutase (SOD), inhibiting D-gal-induced NF-κB upregulation, and increasing PPARs expression in the brain and gut. The findings indicated that PPC has favorable anti-inflammatory and anti-aging properties, and could be useful in the treatment of acute inflammation and senescence diseases.