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Abstract Title:

Anti-inflammatory and anti-Candida effects of Brazilian organic propolis, a promising source of bioactive molecules and functional food.

Abstract Source:

J Agric Food Chem. 2019 Aug 1. Epub 2019 Aug 1. PMID: 31369255

Abstract Author(s):

Bruno Dias Nani, Janaína de Cássia Orlandi Sardi, Josy Goldoni Lazarini, Diego Silva, Adna P Massarioli, Thiago Mattar Cunha, Severino Matias de Alencar, Marcelo Franchin, Pedro Luiz Rosalen

Article Affiliation:

Bruno Dias Nani

Abstract:

Brazilian organic propolis (BOP) is an unexplored Brazilian propolis that is produced organically and certified according to international legislation. Our results showed that BOP has strong anti-inflammatory effects and acts by reducing NF-кB activation, TNF-α release and neutrophil migration. In addition, BOP6 exhibited antifungal activity on planktonic and biofilm cultures of Candida albicans, C. glabrata, C. tropicalis, C. krusei and C. parapsisolis, and it reduced in vitro yeast cell adhesion to human keratinocytes at sub-inhibitory concentrations. BOP demonstrated significantly low toxicity in Galleria melonella larvae at antifungal doses. Lastly, a chemical analysis revealed the presence of caffeoyltartaric acid, 3,4-Dicaffeoylquinic acid, quercetin, gibberellin A7, A9 and A20 in BOP, which may be responsible for the biological properties observed. Thus, our data indicate that BOP is a promising source of anti-inflammatory and antifungal molecules that may be used as a functional food.

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