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Article Publish Status: FREE
Abstract Title:

Anti-Inflammatory and Antioxidant Activity of Pollen Extract Collected by: in silico, in vitro, and in vivo Studies.

Abstract Source:

Antioxidants (Basel). 2020 Jan 24 ;9(2). Epub 2020 Jan 24. PMID: 31991696

Abstract Author(s):

Alberto Jorge Oliveira Lopes, Cleydlenne Costa Vasconcelos, João Batista Santos Garcia, Myssa Sued Dória Pinheiro, Francisco Assis Nascimento Pereira, Darleno de Sousa Camelo, Sebastião Vieira de Morais, José Roberto Brito Freitas, Cláudia Quintino da Rocha, Maria Nilce de Sousa Ribeiro, Maria do Socorro de Sousa Cartágenes

Article Affiliation:

Alberto Jorge Oliveira Lopes

Abstract:

Bees are of great importance for plant diversity for being an important pollinating agents. Stingless bees such as, is cultivated largely due to the products offered by it. Pollen is one of these products, which has been highlighted for exhibit various therapeutic properties. Considering the bioactivity of this natural product, this study investigated the antioxidant, anti-inflammatory, antinociceptive activities, and elucidated the chemical composition of pollen collected extract by. Using in vitro assays, the antioxidant potential and inhibitory activity against the COX enzyme from pollen extract was evaluated. Additionally, tests were performed to measure the anti-inflammatory and antinociceptive activities in animal models. In our results, we found that pollen extract showed antioxidant effects and inhibitory activity against the COX enzyme. The in vivo assays showed that the extract acts on the nervous system in local and systemic levels and that the anti-inflammatory activity is due the prostanoids reducing. Chemical analyses recognize 10 molecules in the extract belonging to the polyphenol and flavonoids classes and the computational study suggests that is responsible for the observed results. Thus, it is reported for the first time the biological potential ofpollen extract and we conclude that this bee product can be considered as one source of potential new drugs.

Study Type : Animal Study, In Vitro Study

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