Anti-inflammatory effect and the effect on acute pharyngitis rats model of compound Lobelia oral liquid.
Saudi J Biol Sci. 2019 Mar ;26(3):577-581. Epub 2018 Nov 26. PMID: 30899174
Objective: Observe anti-inflammatory effect and the effect on acute pharyngitis rats model induced by ammonia water of compound Lobelia oral liquid, providing experimental basis for its clinical use.
Methods: Use egg white establish foot swelling rats model and use carboxymethyl cellulose establish white blood cell migration rats model. Then observe the anti-inflammatory effect of compound Lobelia oral liquid. Use 15% ammonia spray at pharyngeal establish acute pharyngitis rats model, Visual observation and conduct grading of pharyngeal tissue stimulation in rats, measure the levels of TNF-α and IL-6 in serum. Pharyngeal tissue was taken to observe the morphological changes.
Result: All dose groups of compound Lobelia oral liquid can reduce the rate of foot swelling of rats at all time points ( < 0.01 or < 0.05), and significantly reduce the number of white blood cells of rats ( < 0.01); And improve the local hyperemia degree, reduce secretion, reduce local swelling of pharyngeal tissue, reduce the serum TNF-α and IL-6 levels of acute pharyngitis rats with different degrees ( < 0.01 or < 0.05).
Conclusion: Compound Lobelia oral liquid has a good anti-inflammatory effect on foot swelling and white blood cell migration rats model, as well as significant improvement effect on acute pharyngitis rats model.