Anti-inflammatory effect of a flavonoid-rich extract of orange juice in adult zebrafish subjected to-induced enteritis.
Nat Prod Res. 2020 Apr 27:1-4. Epub 2020 Apr 27. PMID: 32338069
Inflammation-related pathologies remain a serious health problem with high costs for the community.flavonoids are known to possess important pharmacological properties, including anti-inflammatory activity. In this study we evaluated the effects of a flavonoid-rich extract of orange juice (OJe) in an experimental model of enteritis induced byin adult zebrafish (). Administration ofthrough live feed (nauplii) for three consecutive days caused evident signs of enteritis in zebrafish. Three days of treatment with OJe before the pathogenic insult resulted in a remarkable reduction of tissue inflammatory events as well as a molecular down-regulation of the inflammatory genes such as IL-1β, IL-6 and TNFα. Our data suggest that OJe counteracts the inflammation of zebrafish intestinal mucosa, indicating that the pool of flavonoids present in orange juice could be useful for the prevention of enteritis.