Article Publish Status: FREE
Abstract Title:

Anti-Inflammatory Effects ofExtract against Lipopolysaccharide-Induced Inflammation in RAW264 Cells.

Abstract Source:

Medicines (Basel). 2021 Aug 4 ;8(8). Epub 2021 Aug 4. PMID: 34436222

Abstract Author(s):

Takashi Tanikawa, Masashi Kitamura, Yasuhiro Hayashi, Natsumi Tomida, Akemi Uwaya, Fumiyuki Isami, Yutaka Inoue

Article Affiliation:

Takashi Tanikawa


Leaves of(noni) have been used in Polynesian folk medicine for the treatment of pain and inflammation, and their juice is very popular worldwide as a functional food supplement. This study aimed to demonstrate thatseed extract exerts anti-inflammatory effects on RAW264 cells stimulated by lipopolysaccharide. To confirm the inhibitory effect ofseed extract, we assessed the production of nitric oxide (NO) and inflammatory cytokines. Theseed extract showed a significant inhibition of NO production, with no effect on cell viability, and was more active thanseed oil, leaf extract, and fruit extract. Theseed extract was found to reduce the expression of inducible NO synthase and tumor necrosis factor-alpha of pro-inflammatory cytokines. These results suggest that the anti-inflammatory effect ofseed extract is related to a reduction in the expression of inflammatory mediators and support its potential therapeutic use.

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