Anti-inflammatory glycosides from the roots of Paeonia intermedia C. A. Meyer. - GreenMedInfo Summary
Anti-inflammatory glycosides from the roots ofC. A. Meyer.
Nat Prod Res. 2019 Aug 27:1-7. Epub 2019 Aug 27. PMID: 31450985
Three new phenolic glycosides, intermedia A-C (-), one new acyclic alcohol glycoside, intermedia D (), together with 3 known glycosides (-), were isolated from the dried roots ofC. A. Meyer. Their structures were established by means of extensive spectroscopic analysis (HRESIMS, NMR). Compoundhave a rare benzo[1,5]dioxepine skeleton. The bioassay results showed that compoundexhibited inhibitory activity against proinflammatory cytokines nitric oxide (NO) secretion in LPS-activated RAW264.7 cells with an ICvalue of 85.76 ± 1.36 μM.