Anti-inflammatory ursane-and oleanane-type triterpenoids from Vitex negundo. - GreenMedInfo Summary
Anti-inflammatory ursane- and oleanane-type triterpenoids from Vitex negundo var. cannabifolia.
J Nat Prod. 2014 Oct 24 ;77(10):2248-54. Epub 2014 Sep 23. PMID: 25245917
Six new polyoxygenated triterpenoids, cannabifolins A-F (1-6), and eight known triterpenoids, 7-14, were isolated from the leaves of Vitex negundo var. cannabifolia. The absolute configuration of cannabifolin A (1) was determined by single-crystal X-ray crystallographic analysis. Compounds 1 and 2 represent a class of rare natural pentacyclic triterpenoids bearing cis-fused C/D rings and are the first examples of 12,19-epoxy ursane- and oleanane-type triterpenoids. Compounds 3, 7, 8, and 14 exhibited inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 values in the range 24.9-40.5μM.