Abstract Title:

Anti-inflammatory ursane- and oleanane-type triterpenoids from Vitex negundo var. cannabifolia.

Abstract Source:

J Nat Prod. 2014 Oct 24 ;77(10):2248-54. Epub 2014 Sep 23. PMID: 25245917

Abstract Author(s):

Man-Man Li, Xiao-Qin Su, Jing Sun, Yu-Fan Gu, Zheng Huang, Ke-Wu Zeng, Qian Zhang, Yun-Fang Zhao, Daneel Ferreira, Jordan K Zjawiony, Jun Li, Peng-Fei Tu

Article Affiliation:

Man-Man Li


Six new polyoxygenated triterpenoids, cannabifolins A-F (1-6), and eight known triterpenoids, 7-14, were isolated from the leaves of Vitex negundo var. cannabifolia. The absolute configuration of cannabifolin A (1) was determined by single-crystal X-ray crystallographic analysis. Compounds 1 and 2 represent a class of rare natural pentacyclic triterpenoids bearing cis-fused C/D rings and are the first examples of 12,19-epoxy ursane- and oleanane-type triterpenoids. Compounds 3, 7, 8, and 14 exhibited inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 values in the range 24.9-40.5μM.

Study Type : In Vitro Study

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