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Abstract Title:

Anti-Influenza Virus Activity of Adlay Tea Components.

Abstract Source:

Plant Foods Hum Nutr. 2019 Nov 15. Epub 2019 Nov 15. PMID: 31728799

Abstract Author(s):

Emiko Nagai, Miwa Iwai, Ritsuko Koketsu, Yoshinobu Okuno, Yuri Suzuki, Ryosuke Morimoto, Hidenobu Sumitani, Atsushi Ohshima, Toshiki Enomoto, Yuji Isegawa

Article Affiliation:

Emiko Nagai

Abstract:

Our previous study showed anti-influenza virus activity in adlay tea prepared from adlay seeds, naked barley seeds, soybean, and cassia seeds. In this study, we evaluated the anti-influenza virus activity of each component of this tea and analyzed their active ingredients. Each component was roasted and extracted in hot water; the extracts were tested for antiviral activity and their mechanisms of action were studied. All the tea components showed antiviral activity against the H1N1 and H3N2 influenza subtypes and against influenza B. The viral stages inhibited by the components were virus adsorption and replication in proliferative process, suggesting that the action mechanisms of the components might differ from those of oseltamivir acid. Of the tea components, soybean showed the strongest activity. Therefore, we analyzed its active ingredients by liquid chromatography quadruple time-of-flight mass spectrometry (LC/qTOF-MS) and daidzein and glycitein were detected as active ingredients. Here, anti-influenza virus action of glycitein was the first report.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1307) : AC(596)

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