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Article Publish Status: FREE
Abstract Title:

Anti-Multiple Myeloma Potential of Secondary Metabolites from.

Abstract Source:

Molecules. 2019 Jul 9 ;24(13). Epub 2019 Jul 9. PMID: 31323932

Abstract Author(s):

Alessio Malacrida, Valeria Cavalloro, Emanuela Martino, Arianna Cassetti, Gabriella Nicolini, Roberta Rigolio, Guido Cavaletti, Barbara Mannucci, Francesca Vasile, Marcello Di Giacomo, Simona Collina, Mariarosaria Miloso

Article Affiliation:

Alessio Malacrida

Abstract:

Multiple myeloma (MM) belongs to hematological cancers and its incidence is increasing worldwide. Despite recent advances in its therapy, MM still causes many deaths every year. In fact, current therapies sometimes fail and are associated with severe adverse effects, including neurotoxicity. As a part of our ongoing efforts to discover new potential therapies against MM, we preparedextracts obtained by a microwave-assisted solvent extraction and investigate their activity by in vitro assays on the RPMI-8226 cell line. The bioguided fractionation of the crude ethanolic extract allowed the identification of HsFC as the most effective extract. We assessed cell viability (MTT and Tripan blue test), cell migration (Boyden chamber assay), and neurotoxicity (DRG neurotoxicity assay). The promising results prompted us to further fractionate HsFC and we obtained two molecules effective against RPMI-8226 cells without neurotoxic effects at their active concentrations. Moreover, both compounds are able to significantly reduce cell migration.

Study Type : In Vitro Study

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