Anti-obesity effects of Morus alba L. and Aronia melanocarpa in a high-fat diet-induced obesity. - GreenMedInfo Summary
Anti-Obesity Effects ofL. andin a High-Fat Diet-Induced Obese C57BL/6J Mouse Model.
Foods. 2021 Aug 18 ;10(8). Epub 2021 Aug 18. PMID: 34441691
Na-Yeon Kim
The present study investigated the synergic effect of extracts of(MA) and(AR) against high-fat diet induced obesity. Four-week-old male C57BL/6J mice were randomly divided into five groups that were fed for 14 weeks with a normal diet (ND), high-fat diet (HD), HD with400 mg/kg body weight (MA), HD with400 mg/kg body weight (AR), or HD with a mixture (1:1,) ofand(400 mg/kg) (MA + AR). Treatment with MA, AR, and MA + AR for 14 weeks reduced high fat diet-induced weight gain and improved serum lipid levels, and histological analysis revealed that MA and AR treatment markedly decreased lipid accumulation in the liver and adipocyte size in epididymal fat. Furthermore, micro-CT images showed MA + AR significantly reduced abdominal fat volume. Expression levels of genes involved in lipid anabolism, such as SREBP-1c, PPAR-γ, CEBPα, FAS, and CD36 were decreased by MA + AR treatment whereas PPAR-α, ACOX1, and CPT-1a levels were increased by MA + AR treatment. Protein expression of p-AMPK and p-ACC were increased in the MA + AR group, indicating that MA + AR ameliorated obesity by upregulating AMPK signaling. Together, our findings indicate that MA and AR exert a synergistic effect against diet-induced obesity and are promising agents for managing obesity.