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Abstract Title:

Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin.

Abstract Source:

Exp Oncol. 2020 06 ;42(2):101-108. PMID: 32602283

Abstract Author(s):

H Lamdan, R S Garcia-Lazaro, N Lorenzo, L G Caligiuri, D F Alonso, H G Farina

Article Affiliation:

H Lamdan

Abstract:

BACKGROUND: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties.

AIM: In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin.

MATERIALS AND METHODS: A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated.

RESULTS: Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells.

CONCLUSION: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro.

Study Type : In Vitro Study

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