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Abstract Title:

Anti-quorum sensing and biofilm inhibitory activity ofL. oleoresin.

Abstract Source:

J Food Sci Technol. 2020 Jul ;57(7):2414-2422. Epub 2020 Jan 28. PMID: 32549591

Abstract Author(s):

Nupur Nagar, Jamuna Bai Aswathanarayan, Ravishankar Rai Vittal

Article Affiliation:

Nupur Nagar

Abstract:

L. (Apiaceae) is a dietary herb used as a spice, condiment and medicine.(Celery) has been studied for its antimicrobial property and for its application as flavours in food industry. The present study investigated theoleoresin as an anti-quorum sensing and antibiofilm agent. The quorum sensing and biofilm inhibition study was carried out using biosensor strainsCV12472 andPAO1. The MIC of celery oleoresin againstCV12472 andPAO1 was 10 and 25% v/v, respectively. Inhibition of violacein and biofilm formation was tested at concentrations of oleoresins ranging from 1.56 and 50% v/v. The oleoresins showed a concentration dependent QS inhibitory activity and at sub-MIC of 6.25 and 12.5% v/v, the oleoresins significantly inhibited violacein production and biofilm formation ( < 0.05). Similarly, the celery oleoresin had significant QS modulatory effect on swimming, swarming and twitching motility inPAO1 at 12.5% v/v ( < 0.05). The major phytoconstituents present in celery oleoresin as analysed by GC-MS were eicosadiene, benzenemethanol and methyl ester which have not been previously reported. The findings suggest that celery has QS and biofilm inhibitory potential against gram negative pathogens and can find application as food intervention techniques.

Study Type : In Vitro Study

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