Article Publish Status: FREE
Abstract Title:

Anti-stress effects of the hydroalcoholic extract ofin mice.

Abstract Source:

Heliyon. 2019 Jun ;5(6):e01945. Epub 2019 Jun 14. PMID: 31431930

Abstract Author(s):

Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Yuko Fujiwara, Takeshi Ishihara

Article Affiliation:

Hiroshi Ueno


, a plant of thegenus, has been used widely since the 13century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects ofremain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract ofin male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract ofto mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the-treated mice than in the control mice. The oral administration ofdid not affect the normal behavior of mice. However, when the mice were subjected to stress,exerted an anti-stress effect. Therefore,has potential as a medicinal plant for the purpose of stress prevention.

Study Type : Animal Study
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