Do Vitamin D Levels Affect Antibody Titers Produced in Response to HPV Vaccine?
Hum Vaccin Immunother. 2015 Jul 15:0. Epub 2015 Jul 15. PMID: 26176493
Richard K Zimmerman
In addition to its well-known effects on bone metabolism, vitamin D is an immunomodulating hormone. Serum vitamin D levels in males 18-25 years were measured at baseline, and HPV antibody titers were measured one month following the third quadrivalent HPV vaccine dose. Vitamin D levels were>30 ng/ml (normal) in 60 males and<30 ng/ml (low) in 113 males. Reverse cumulative distribution curves and scatter plots showed higher antibody titers with low vitamin D for all vaccine strains (P<0.05). In linear regression analyses, antibody titers for all HPV strains were significantly higher among those with lower vitamin D levels and among younger participants (P<0.05). These relationships add to the body of knowledge of the complex role of vitamin D in immunoregulation.