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Abstract Title:

Anticancer Activity of.

Abstract Source:

Cancers (Basel). 2018 Sep 26 ;10(10). Epub 2018 Sep 26. PMID: 30261584

Abstract Author(s):

Mouna Sdiri, Xiangmin Li, William W Du, Safia El-Bok, Yi-Zhen Xie, Mossadok Ben-Attia, Burton B Yang

Article Affiliation:

Mouna Sdiri

Abstract:

The extensive applications ofspecies and their rich bioactive secondary metabolites have inspired many pharmacological investigations. Previous research has been conducted to examine the biological activities and numerous interesting pharmaceutical activities have been reported. However, the antitumor activities of these species are unclear. To understand the potential anticancer activity, we screenedandusing three different extracts of each species. In this study, the selected extracts were evaluated for their ability to decrease survival rates of five different cancer cell lines. We compared the cytotoxicity of the three different extracts to the anticancer drug vinblastine and one of the most well-known medicinal mushrooms. We found that the water and alcohol extracts ofat the very low concentrations possessed very high capacity in decreasing the cancer cells viability with a potential inhibition of tumorigenesis. Based on these primitive data, we subsequently tested the ethanol and the water extracts of, respectively in in vitro and in vivo assays. Cell cycle progression and induction of programmed cell death were investigated at both biological and molecular levels to understand the mechanism of the antitumor inhibitory action of the. The in vitro experiments showed that the treated cancer cells formed fewer and smaller colonies than the untreated cells. Cell cycle progression was inhibited, and the ethanol extract ofat a low concentration induced accumulation of cells in the G1 phase. We also found that the's extracts suppressed viability of two murine cancer cell lines. In the in vivo experiments, we injected mice with murine cancer cell line B16, followed by peritoneal injection of the water extract. The treatment prolonged mouse survival significantly. The tumors grew at a slower rate than the control. Down-regulation of c-myc expression appeared to be associated with these effects. Further investigation showed that treatment withinduced the overexpression of the tumor suppressor Foxo3 and other molecules involved in inducing autophagy. These results showed that theextract exerts its antiproliferative activity through the induction of cell death pathway. Thus, theplants appear to be a promising source of new antineoplastic compounds.

Study Type : Animal Study, In Vitro Study

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