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Abstract Title:

Anticancer effects of root and beet leaf extracts (Beta vulgaris L.) in cervical cancer cells (HeLa).

Abstract Source:

Phytother Res. 2021 Sep 8. Epub 2021 Sep 8. PMID: 34494317

Abstract Author(s):

Stefhani Andrioli Romero, Isadora Carolina Betim Pavan, Ana Paula Morelli, Mariana Camargo Silva Mancini, Luiz Guilherme Salvino da Silva, Isabella Fagundes, Cayo Henrique Rocha Silva, Luis Gustavo Saboia Ponte, Mauricio Ariel Rostagno, Rosângela Maria Neves Bezerra, Fernando Moreira Simabuco

Article Affiliation:

Stefhani Andrioli Romero

Abstract:

Cervical cancer is the fourth leading cause of cancer mortality in women worldwide. Beetroot (Beta vulgaris L.) has bioactive compounds that can inhibit the progression of different types of cancer. To analyze the antiproliferative effects of beet leaf and root extracts, we performed MTT, clonogenic survival, cell cycle analysis, Annexin/PI labeling, and western blotting. Here, we report that 10 and 100 μg/ml of root and leaf extracts decreased cell viability and potentiated rapamycin and cisplatin effects while decreased the number of large colonies, especially at 10 μg/ml (293.6 of control vs. 200.0 of leaf extract, p = .0059; 138.6 of root extract, p = .0002). After 48 hr, 100 μg/ml of both extracts led to increased sub-G1 and G0/G1 populations. In accordance, 100 μg/ml of root extract induced early apoptosis (mean = 0.64 control vs. 1.56 root; p = .048) and decreased cell size (p < .0001). Both extracts decreased phosphorylation and expression of mechanistic Target of Rapamycin (mTOR) signaling, especially by inhibiting ribosomal protein S6 (S6) phosphorylation, increasing cleaved poly(ADP-ribose) polysomerase 1 (PARP1) and Bcl-2-like protein 11 (BIM), and decreasing cyclinD1 expression, which regulates cell cycle progression. Here, we demonstrate that beetroot and leaf extracts could be an efficient strategy against cervical cancer.

Study Type : In Vitro Study

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Sayer Ji
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