Article Publish Status: FREE
Abstract Title:

Antidepressant effects of aqueous extract of saffron and its effects on CREB, P-CREB, BDNF, and VGF proteins in rat cerebellum.

Abstract Source:

J Pharmacopuncture. 2018 Mar ;21(1):35-40. Epub 2018 Mar 31. PMID: 30151303

Abstract Author(s):

Najmeh Asrari, Rezvan Yazdian-Robati, Khalil Abnous, BiBi Marjan Razavi, Mrazieh Rashednia, Faezeh Vahdati Hasani, Hossein Hosseinzadeh

Article Affiliation:

Najmeh Asrari


Objective: The role of BDNF (brain-derived neurotrophic factor), CREB (cAMP response element binding) and VGF neuropeptide has been proved in antidepressant activity of long term saffron administration in the rat hippocampus. In this study we evaluated the role of these proteins in antidepressant activity of saffron in long term administration in the rat cerebellum.

Methods: Saffron aqueous extract (40 and 80 mg/kg/day) and imipramine (10 mg/kg/day) were administered intraperitoneally for 21 days to rats. At the end of experiment, animals were sacrificed and cerebellums were separated. The protein levels of BDNF, VGF, CREB and P- CREB in the rat cerebellum were evaluated using western blot analysis.

Results: Saffron aqueous extract (80mg/kg/day) caused significant increase in protein level of P-CREB in long term treatment in the rat cerebellum. The increases in the protein levels of VGF, CREB and BDNF were not significant.

Conclusion: In summary, our results showed that antidepressant effect of saffron in rat cerebellum might be due to the enhanced phosphorylation of CREB.

Study Type : Animal Study
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