Antifungal and Antivirulence Activity of VaginalSpp. Products againstVaginal Isolates.
Pathogens. 2019 Sep 12 ;8(3). Epub 2019 Sep 12. PMID: 31547398
Camilla Itapary Dos Santos
yeasts are generally found in the vaginal microbiota; however, disruption of the balance maintained by host factors and microorganisms results in vulvovaginal candidiasis (VVC). This study evaluated the antagonistic activity of vaginalspp. onto verify whether active compounds ofspp. had antifungal and antivirulence activity. The antagonism assay showed that 15 out of 20strains had an inhibitory effect onBiosurfactants displayed surface-tension-reducing activity, with the best value obtained for1.ATCC 9595,ATCC 4356, and11 produced biosurfactants that decreasedadhesion and disrupted biofilm formation. The best results were obtained in the pre-incubation assay for1 and11. Overall,strains showed significant anti-activity, and their biosurfactants exhibited considerable anti-adhesion and antibiofilm activity against. To be considered safe for use in vivo, the safety of biosurfactant (BS) should be investigated using cytotoxicity assays.