Antifungal effect of the bark and root extracts of Punica granatum on oral Candida isolates. - GreenMedInfo Summary
Antifungal effect of the bark and root extracts ofon oralisolates.
Curr Med Mycol. 2018 Dec ;4(4):20-24. PMID: 30815613
Background and Purpose: Oral candidiasis is one of the most common fungal infections in humans. The treatment and prophylaxis of the patients suffering from this infection require the identification of new anti-agents with no side effects or toxicity like medicinal plants. The present study was conducted to compare the antifungal activities of the aqueous, ethanolic, and methanolic extracts of the bark and roots ofwith those of two routine antifungal agents (i.e., fluconazole and nystatin) on oralstrains isolated from liver transplant recipients.
Materials and Methods: Minimum inhibitory concentrations (MICs) of the ethanolic, methanolic, and aqueous extracts of the bark and root ofagainstandisolated from oral cavities were evaluated according to the CLSI M27-A3. All data were analyzed in SPSS (version 16.0) by pairwise comparison and Kruskal-Wallis test.
Results: The MIC50 and MIC90 values for the methanolic and ethanolic extracts of the bark and root ofagainstwere both obtained as 0.05 mg/ml with the geometric mean (GM) of 0.07. Furthermore, the MIC90 values for the aqueous extracts of bark and root were estimated as 0.05 and 0.2 mg/ml, respectively. With regard tothe MIC50 and MIC90 values for the methanolic and ethanolic extracts of the bark and root were 0.05 mg/ml. However, the MIC90 value for the aqueous extract against this species was obtained as 25 mg/ml. The GM values for the aqueous extracts of the bark and root were 9.49 and 0.32, respectively.
Conclusion: As the findings indicated, the methanolic and ethanolic extracts of the bark and root ofhad anti-activities. Therefore, they can be considered as mouthwash or toothpaste to prevent and treatinfections in the oral cavity.