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Article Publish Status: FREE
Abstract Title:

Antigout Effects of: Xanthine Oxidase Inhibitory Activities Assessed by Electrochemical Biosensing Method.

Abstract Source:

Evid Based Complement Alternat Med. 2018 ;2018:1364617. Epub 2018 Feb 22. PMID: 29681967

Abstract Author(s):

Jin-Xiang Zeng, Juan Wang, Shou-Wen Zhang, Ji-Xiao Zhu, Min Li, Wei-Hua Huang, Jin-Yi Wan, Hai-Qiang Yao, Chong-Zhi Wang, Chun-Su Yuan

Article Affiliation:

Jin-Xiang Zeng

Abstract:

The XOD inhibitory effects of Plantaginis Semen, that is, the seeds of, and its representative four single compounds, acteoside, 1H-indolo-3-carbaldehyde, isoacteoside, and myristic acid, were evaluated by electron transfer signal blocking activities (ETSBA), which is based on the electron transfer signal of XOD enzymatic reaction. The blocking activities were detected using an electrochemical biosensing method. Compared with control, significant effects were observed after the addition ofextract, acteoside, and 1H-indolo-3-carbaldehyde (all<0.05). The IC50 values of the extract and acteoside are 89.14 and 7.55 g·mL, respectively. The IC20 values of the extract, acteoside, and 1H-indolo-3-carbaldehyde are 24.28, 3.88, and 16.16 g·mL, respectively. Due to the relatively lower inhibitory potential of 1H-indolo-3-carbaldehyde, its IC50 was not obtained. In addition, isoacteoside and myristic acid did not show any XOD inhibitory effects. Our data demonstrated that the XOD inhibitory effects of the extract, acteoside, and 1H-indolo-3-carbaldehyde can be accurately evaluated by the ETSBA method. The results from this study indicated that Plantaginis Semen significantly inhibited XOD activities to reduce hyperuricemia and treat gout. The study also proves that measuring the electron transfer signal blocking activities is a simple, sensitive, and accurate method to evaluate the XOD inhibitory effects.

Study Type : In Vitro Study

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