Gastrodin Reduces Blood Pressure by Intervening with RAAS and PPARγ in SHRs.
Evid Based Complement Alternat Med. 2015 ;2015:828427. Epub 2015 Oct 26. PMID: 26587048
Gastrodin is a bioactive compound extracted from traditional Chinese medicine, Gastrodia elata Bl. It has a definite effect on reducing blood pressure in hypertensive patients. However, the mechanisms of gastrodin in lowering blood pressure still remain unclear. In this study, 4 weeks of administration of gastrodin (100 mg/kg/d intraperitoneally injected) decreased the systolic bloodpressure (SBP) in spontaneously hypertensive rats (SHRs) (190.2 ± 8.9 versus 169.8 ± 6.4, P<0.01). Among SHRs receiving gastrodin treatment, angiotensin II (Ang II) and aldosterone (ALD) in serum were significantly decreased (2022.1± 53.0 versus 1528.7 ± 93.9, 213.33 ± 35.17 versus 179.65 ± 20.31, and P<0.01, P<0.05, resp.) and dramatically downregulated expression of angiotensin type 1 receptor (AT1R) (4.9± 0.9 versus 2.6 ± 0.9, P<0.05) in myocardium in both mRNA and protein levels compared with their corresponding groups without gastrodin treatment. Additionally, gastrodin increased the mRNA expression (0.18± 0.07 versus 0.82 ± 0.10, P<0.01) and protein synthesis (0.40± 0.10 versus 0.34 ± 0.10, P<0.01) of peroxisome proliferator-activated receptorγ (PPARγ) in myocardium tissues. Overall, our data demonstrated that gastrodin was able to decrease the SBP in SHR. Furthermore, this study showed that gastrodin intervened with the renin-angiotensin-aldosterone system (RAAS) and PPARγ effectively, which indicates its antihypertensive mechanism.