n/a
Article Publish Status: FREE
Abstract Title:

Gastrodin Reduces Blood Pressure by Intervening with RAAS and PPARγ in SHRs.

Abstract Source:

Evid Based Complement Alternat Med. 2015 ;2015:828427. Epub 2015 Oct 26. PMID: 26587048

Abstract Author(s):

Wei Liu, Lingyan Wang, Jiahui Yu, Patrick Fordjour Asare, Ying-Qiang Zhao

Article Affiliation:

Wei Liu

Abstract:

Gastrodin is a bioactive compound extracted from traditional Chinese medicine, Gastrodia elata  Bl. It has a definite effect on reducing blood pressure in hypertensive patients. However, the mechanisms of gastrodin in lowering blood pressure still remain unclear. In this study, 4 weeks of administration of gastrodin (100 mg/kg/d intraperitoneally injected) decreased the systolic bloodpressure (SBP) in spontaneously hypertensive rats (SHRs) (190.2 ± 8.9 versus 169.8 ± 6.4, P<0.01). Among SHRs receiving gastrodin treatment, angiotensin II (Ang II) and aldosterone (ALD) in serum were significantly decreased (2022.1± 53.0 versus 1528.7 ± 93.9, 213.33 ± 35.17 versus 179.65 ± 20.31, and P<0.01, P<0.05, resp.) and dramatically downregulated expression of angiotensin type 1 receptor (AT1R) (4.9± 0.9 versus 2.6 ± 0.9, P<0.05) in myocardium in both mRNA and protein levels compared with their corresponding groups without gastrodin treatment. Additionally, gastrodin increased the mRNA expression (0.18± 0.07 versus 0.82 ± 0.10, P<0.01) and protein synthesis (0.40± 0.10 versus 0.34 ± 0.10, P<0.01) of peroxisome proliferator-activated receptorγ (PPARγ) in myocardium tissues. Overall, our data demonstrated that gastrodin was able to decrease the SBP in SHR. Furthermore, this study showed that gastrodin intervened with the renin-angiotensin-aldosterone system (RAAS) and PPARγ effectively, which indicates its antihypertensive mechanism.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.