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Article Publish Status: FREE
Abstract Title:

Antimicrobial Activity of DifferentEssential Oil Formulations.

Abstract Source:

Molecules. 2020 May 21 ;25(10). Epub 2020 May 21. PMID: 32455592

Abstract Author(s):

Sourav Das, Barbara Vörös-Horváth, Tímea Bencsik, Giuseppe Micalizzi, Luigi Mondello, Györgyi Horváth, Tamás Kőszegi, Aleksandar Széchenyi

Article Affiliation:

Sourav Das

Abstract:

The extreme lipophilicity of essential oils (EOs) impedes the measurement of their biological actions in an aqueous environment. We formulated oil in water type PickeringEO nanoemulsions (AEP) with surface-modified Stöber silica nanoparticles (20 nm) as the stabilizing agent. The antimicrobial activity of AEP and its effects on maturebiofilms were compared with those of Tween 80 stabilized emulsion (AET) and ethanolic solution (AEE) of theEO. The antimicrobial activity was evaluated by using the minimum inhibitory concentrations (MIC) and minimum effective concentrations (MEC) of the compounds. On planktonic bacterial and fungal cells beside growth inhibition, colony formation (CFU/mL), metabolic activity, viability, intracellular ATP/total protein (ATP/TP), along with reactive oxygen species (ROS) were also studied.EO nanoemulsion (AEP) showed significantly higher antimicrobial activity than AET and AEE.EO nanoemulsions (AEP) generated superoxide anion and peroxides-related oxidative stress, which might be the underlying mode of action of theEO. Unilamellar liposomes, as a cellular model, were used to examine the delivery efficacy of the EO of our tested formulations. We could demonstrate higher effectiveness of AEP in the EO components' donation compared to AET and AEE. Our data suggest the superiority of the AEP formulation against microbial infections.

Study Type : In Vitro Study

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