Abstract Title:

The anticancer effect of antineoplaston A-10 on human breast cancer serially transplanted to athymic mice.

Abstract Source:

Nihon Gan Chiryo Gakkai Shi. 1990 Jan 20 ;25(1):1-5. PMID: 2157780

Abstract Author(s):

K Hashimoto, T Koga, Y Shintomi, M Tanaka, T Kakegawa, H Tsuda, H Hara

Article Affiliation:

1st Department of Surgery, Kurume University School of Medicine.


We report the effects of Antineoplaston A-10 Injection on the growth curve of human breast cancer (R-27) serially transplanted to athymic mice. The intraperitoneal administration of 1/4 LD-50 (50 mg/mouse) of Antineoplaston A-10 Injection every day and 1/2 LD-50 (100 mg/mouse) every other day for 35 days was found to significantly inhibit the growth curve and also the 3H-TdR uptake was inhibited by 73.7% in those given 1/4 LD-50 and by 77.1% in those given 1/2 LD-50. The tumor histology in both groups showed necrosis but no lymphocyte infiltration.

Study Type : Transgenic Animal Study
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