Antiobesity efficacy of asiatic acid. - GreenMedInfo Summary

Abstract Title:

Antiobesity efficacy of asiatic acid: down-regulation of adipogenic and inflammatory processes in high fat diet induced obese rats.

Abstract Source:

Arch Physiol Biochem. 2019 Feb 10:1-10. Epub 2019 Feb 10. PMID: 30739501

Abstract Author(s):

V V Sathibabu Uddandrao, P Rameshreddy, P Brahmanaidu, Ponmurugan Ponnusamy, Santhanaraj Balakrishnan, Ravindar Naik Ramavat, K Swapna, Suresh Pothani, Harishankar Nemani, Balaji Meriga, S Vadivukkarasi, Nivedha P R, Saravanan Ganapathy

Article Affiliation:

V V Sathibabu Uddandrao


In the current study, we evaluated the effects of Asiatic acid (AA) on lipid metabolic markers in HFD-induced obese Sprague-Dawley rat model. AA (20 mg/kg BW) was administered orally to HFD-fed rats for 42 days. Changes in body composition, glucose, insulin resistance (IR) and lipid profiles of tissues, plasma and the pattern of gene expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) and its target genes fatty-acid synthase (FAS), adipocyte protein-2 (aP2) and uncoupling protein-2 (UCP-2) and pro-inflammatory factor tumor necrosis factor (TNF)-α were observed in experimental rats. Oral administration of AA exerts therapeutic effects similar to orlistat in attenuating body weight gain, glucose, IR, plasma and tissuelipids and mRNA levels of PPAR-γ, FAS, aP2 and inflammatory factor TNF-α and increasing UCP-2 expression in HFD-fed rats. Hence, these findings concluded that AA attenuate HFD-induced obesity by modulating PPAR-γ and its target genes and regulate lipid metabolism, suggesting their possible antiobesity effects.

Study Type : Animal Study

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