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Abstract Title:

Antioxidant Capacity of Thistle (Cirsium japonicum) in Various Drying Methods and their Protection Effect on Neuronal PC12 Cells and.

Abstract Source:

Antioxidants (Basel). 2020 Feb 28 ;9(3). Epub 2020 Feb 28. PMID: 32121091

Abstract Author(s):

Miran Jang, Kee-Hong Kim, Gun-Hee Kim

Article Affiliation:

Miran Jang

Abstract:

The aim of this study was, firstly, to evaluate the phenol profile of thistle (, CJ) by High performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS), dried by different methods (90°C hot-air, 70 °C hot-air, shade-, and freeze-drying). Secondly, we aimed to evaluate the relationship between phenolic compounds content and antioxidant properties. CJ contained chlorogenic acid, linarin, and pectolinarin. Total phenolic contents of CJ significantly decreased under hot-air-dryingcondition, especially chlorogenic acid contents in CJ have been reduced by 85% and 60% for 90 °C and 70 °C hot-air-drying, respectively. We evaluated the protective effect on adrenal pheochromocytoma (PC12) cells andusing shade-dried CJ, which has the largest phenolic contents and the strongest antioxidant property. CJ-treated PC 12 cells dose-dependently exhibited the protective effects against reactive oxygen species (ROS), while cell viability increases, lactate dehydrogenase release decreases, and ROS formation decreases. Furthermore, CJ has also shown protection against ROS inConsequently, CJ contributed to lifespan extension under ROS stress without influencing the physiological growth.

Study Type : Animal Study

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