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Article Publish Status: FREE
Abstract Title:

Antiproliferative and cytotoxic effects of grape pomace and grape seed extracts on colorectal cancer cell lines.

Abstract Source:

Food Sci Nutr. 2019 Sep ;7(9):2948-2957. Epub 2019 Aug 2. PMID: 31572588

Abstract Author(s):

José M Pérez-Ortiz, Luis F Alguacil, Elisabet Salas, Isidro Hermosín-Gutiérrez, Sergio Gómez-Alonso, Carmen González-Martín

Article Affiliation:

José M Pérez-Ortiz

Abstract:

Grape pomace is the source of bioactive compounds (anthocyanins, flavonols, flavan-3-ols, and stilbenes) which exhibit antiproliferative actions on cell cultures. We have investigated the antitumoral effects of grape pomace and grape seed extracts on colon cancer cells (Caco-2, HT-29) and fibroblasts. Crude extracts prepared from white and red pomace, and grape seeds, reduced the viability and proliferation of Caco-2. HT-29 cells were resistant to these actions. Purified extracts were then prepared from the same sources and compared with the LDH test; again, all three extracts were active and purified extract from grape seed was the most potent and specific on Caco-2 cells. HT-29 cells were more sensitive to these purified extracts. The biological activity resided almost exclusively in the flavonol and flavan-3-ols subfractions, rather than the anthocyanin subfraction. Preliminary results on the mechanisms involved in these effects revealed downregulation of Myc gene expression in HT-29 and upregulation of Ptg2 in Caco-2 cells.

Study Type : In Vitro Study

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