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Article Publish Status: FREE
Abstract Title:

Anxiolytic-Like Effects of Bergamot Essential Oil Are Insensitive to Flumazenil in Rats.

Abstract Source:

Evid Based Complement Alternat Med. 2019 ;2019:2156873. Epub 2019 Aug 14. PMID: 31485242

Abstract Author(s):

Laura Rombolà, Damiana Scuteri, Annagrazia Adornetto, Marilisa Straface, Tsukasa Sakurada, Shinobu Sakurada, Hirokazu Mizoguchi, Maria Tiziana Corasaniti, Giacinto Bagetta, Paolo Tonin, Luigi Antonio Morrone

Article Affiliation:

Laura Rombolà

Abstract:

Anxiety disorders are one of the most common mental disorders, and benzodiazepines (BDZs), acting on gamma-aminobutyric acid type A (GABA-A) receptor complex, represent the most common antianxiety medications in the world. However, chronic BDZ use elicits several adverse reactions. Reportedly, aromatherapy is safer for the management of anxiety. Bergamot essential oil (BEO) extracted fromRissoPoiteau fruit, like other essential oils, is widely used in aromatherapy to relieve symptoms of stress-induced anxiety. Interestingly, preclinical data indicate that BEO induces anxiolytic-like/relaxant effects in animal behavioural tasks not superimposable to those of benzodiazepine diazepam. To better elucidate the involvement of GABAergic transmission, the present study examines the effects of pretreatment with flumazenil (FLZ), a benzodiazepine site antagonist, on BEO effects using open-field task (OFT) in rats. The data yielded show that FLZ does not significantly affect behavioural effects of the phytocomplex. These results demonstrate the lack of overlapping between BEO and BDZ behavioural effects, contributing to the characterization of the neurobiological profile of the essential oil for its rational use in aromatherapy.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Anti-Anxiety Agents : CK(356) : AC(59)

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